



Advair
Generic Name:
Fluticasone, Salmeterol
Brand Names:
Advair Diskus, Advair HFA, Seretide (EU, Australia), Adoair (Japan), Viani (Germany), ForAir (India)
Advair Description:
Advair is a medication used to treat asthma and chronic obstructive pulmonary disease (COPD). It is inhaled into the body and actually consists of two medications in one: a steroid and a form of albuterol (in order to reduce inflammation in the lungs and prevent attacks). The drug is distributed by GlaxoSmithKline and works by reducing inflammation and preventing airway constriction. This reduces the symptoms caused by asthma and COPD, which can include coughing and shortness of breath.
Advair Uses:
Advair is used for the treatment and maintenance of asthma and COPD. Intended for those over the age of 4, Advair is used twice a day for maintaining asthma on a long-term basis. This is not a drug meant for treating asthma attacks or sudden breathing problems but functions as a preventative measure. Asthma is a lung disease that causes the airways in the lungs to narrow and become inflamed. Those with asthma typically experience symptoms such as coughing, wheezing and shortness of breath. While asthma usually occurs first in childhood, it can affect anyone. Asthma can result in the tightening of the muscles around the airways, constricting airways and limiting the amount of air that can enter the body. Swelling can result and the irritation can cause mucus to build up in the airways, leaving breathing further restricted.
Advair is also used to treat COPD, which is a condition that includes emphysema and chronic bronchitis. Emphysema occurs when the alveoli or air sacs in the lungs become damaged which can result in fewer enlarged air sacs, rather than several small ones. Chronic obstructive bronchitis causes the airway lining to become inflamed. The constant irritation leaves the lining thicker than normal and covered in mucus, making it harder to breathe. Advair is used for this condition because it works to open up obstruction in the airways of the lungs and reduces inflammation and irritation caused by these diseases. It is advised that Advair be taken twice a day to keep the airway open and stave off typical COPD symptoms, which consist of coughing that produces mucus, shortness of breath and wheezing. COPD is usually caused by long-term cigarette smoking or exposure to other irritants like smog, chemicals and pollutants.
Advair Interactions:
Do not use salmeterol, formoterol, or other inhalers that contain a long-acting beta agonist (LABA) while taking Advair, as they contain the same active ingredient. The effects of Advair may be altered if you are already taking antidepressants (tricyclics or monoamine oxidase inhibitors), beta blockers, Ketoconazole, long-acting inhalers, Ritonavir, or diuretics (water pills). Notify your doctor before starting Advair if you take these medications.
Advair Dosage Information:
Typical Dosage Recommendation:
Advair Diskus is available in three strengths—100/50, 250/50, and 500/50, containing 100, 250, and 500 mcg of fluticasone propionate, respectively, and 50 mcg of salmeterol per inhalation of each preloaded dose in the blister pack. Adults 12 years of age and older should use one inhalation twice daily, with the inhalations taken in the morning and in the evening, 12 hours apart. Advair HFA is also available in three strengths—45/21, 115/21, 230/21, containing 45, 115, and 230 mcg of fluticasone propionate respectively, and 21 mcg of salmeterol per inhalation. The inhaler should be primed before first use, and the recommended dosage is 2 inhalations, twice per day (with the doses 12 hours apart).
Missing a Dose:
Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not take two doses at one time.
Overdosing:
Seek emergency medical attention if you think you have used too much. Overdose symptoms may include angina or chest pain, fast or irregular heartbeats, seizures, tremor, weakness, headache, nausea, and vomiting.
Advair FDA Approval:
Advair Diskus approved August 24, 2000; Advair HFA approved June 8, 2006
Advair Recall/Black Box Warning Information:
The FDA placed a Black Box warning on all salmeterol products, including Advair, in August 2003, as some studies indicated that salmeterol could increase the risk of suffering from a fatal asthma attack while using this product, particularly in African American patients. However, the FDA maintains that the benefits of the medications far outweigh the possible risks.
Sources:
- http://www.advair.com/
- http://www.mayoclinic.com/health/drug-information/DR600459
- http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=ADVAIR%20DISKUS%20100%2F50
- http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=ADVAIR%20DISKUS%20250%2F50
- http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=ADVAIR%20DISKUS%20500%2F50
- http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=ADVAIR%20HFA
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May 9, 2011, 1:27 pm
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