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Enjuvia Side Effects

These side effects, though common to Enjuvia usage, should be discussed with your doctor if they become severe or wearisome:

  • Changes in appearance or frequency of vaginal discharge
  • Difficulty breathing
  • Pain in the breasts
  • Rapid weight gain
  • Redness or rash-like appearance on skin
  • Swelling of eyelids, lips and breasts
  • Trouble in swallowing
  • Wheezing

Some side effects of Enjuvia can be serious. Contact a doctor immediately if you experience any of the following adverse reactions to Enjuvia:

  • Feeling of pressure in the pelvic region
  • Anxiety
  • Backache or abdominal cramps
  • Bleeding of gums
  • Blurred or double vision
  • Change in color of the stool
  • Change in skin color
  • Changes in taste like sour or acid mouth
  • Depression
  • Excessive thirst
  • Heart burn
  • Increase in skin sensitivity (especially toward the sun)
  • Loss of coordination
  • Confusion
  • Migraine headaches
  • Mood swings or mental changes
  • Numbness in legs
  • Pain in legs (especially the calves)
  • Redness of skin, eyes or breast
  • Shortness of breath
  • Slurring of speech
  • Sudden and severe headache
  • Sudden onset of dizziness which slowly disappears
  • Swelling of abdominal area
  • Vomiting
Things to Know, Precautions, Things to Ask Your Physician: 

Post-menopausal women may begin to experience vaginal bleeding again following use of Enjuvia. This may continue as long as the medicine is taken. Typically, if estrogen is taken as a long term medicine, unusual vaginal bleeding will cease within in 10 months.

Prolonged use of Enjuvia may cause endometrial cancer. Risk of endometrial cancer is reduced if estrogen is taken in small dosages for a period less than a year. If progestin is given along with or replaces estrogen, the risk of cancer is significantly reduced. There is no risk of endometrial cancer in women who have undergone a hysterectomy or had their uterus removed.

Patients with a history of blood clots should take Enjuvia with extreme caution as it may lead to stroke, heart attack or, in some cases, even death. This typically occurs in men who are prescribed estrogen. Men with estrogen intake may also have the risk of developing breast cancer.

Patients should inform their doctor of any allergy towards estrogen or any other drug.

The herbal drug St. Johns Wort must be taken only after a doctor’s consent as it may reduce the effect of Enjuvia.

Enjuvia must be taken only after informing a doctor if a patient has experienced:

  • Yellowing of eyes during pregnancy
  • Endometriosis
  • Uterine fibroids
  • Asthma
  • Migraine headaches
  • Seizures
  • Porphyria
  • High or low levels of calcium in blood
  • Heart, liver, kidney, gall bladder or pancreatic disease or disorder

If you become pregnant while taking Enjuvia, immediately inform your doctor as estrogen can pass through the human placental cord and may adversely affect the fetus.

Before beginning Enjivia, tell the doctor your medical history, paying special attention to a history of:

  • Allergies
  • Asthma
  • Cholesterol or lipid problems
  • Depression
  • Diabetes
  • Heart disease (heart attacks, high blood pressure, congestive heart failure),
  • High blood pressure in the course of pregnancy (toxemia)
  • Hypothyroidism (low thyroid hormone)
  • Kidney disease 
  • Migraine headaches
  • Seizures
  • Unusual  level of calcium in the blood
  • Womb problems (e.g., uterine fibroids endometriosis)
What to Avoid When Taking the Drug: 

If Enjuvia is taken to prevent osteoporosis, a doctor may also suggest taking calcium  supplements.

 Avoid drinking large amounts of grapefruit juice when taking Enjuvia.

Avoid smoking and being exposed to smoke while taking Enjuvia.

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