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Limbitrol

Generic Name: 

Chlordiazepoxide and amitriptyline

Brand Names: 

Limbitrol, Limbitrol DS

Limbitrol Description: 

Limbitrol is a combination antidepressant and tranquilizer medication prescribed to treat moderate to severe depression caused by anxiety and tension. Limbitrol is a combination of chlordiazepoxide, anti-anxiety drug, and amitriptyline, an antidepressant.

Limbitrol Side Effects: 

Common side effects of Limbitrol include:

  • Bloating
  • Blurred vision
  • Constipation
  • Dizziness
  • Drowsiness
  • Dry mouth

For more information, see our Limbitrol side effects page.

Limbitrol Uses: 

Limbitrol is used to treat the following symptoms associated with depression and anxiety, including:

  • Agitation
  • Feelings of guilt or worthlessness
  • Insomnia
  • Loss of appetite
  • Suicidal thoughts
Limbitrol Interactions: 

Tell your doctor about all prescription and non-prescription medications you may be taking along with Limbitrol, including vitamins, nutritional supplements, and herbal products. The following drugs may cause interactions with this medication:

  • Antidepressants
  • Antihistamines
  • Cimetidine (Tagamet)
  • Citalopram (Celexa)
  • Digoxin (Lanoxin)
  • Disulfiram (Antabuse)
  • Escitalopram (Lexapro)
  • Flecainide (Tambocor)
  • Fluoxetine (Prozac, Luvox)
  • Guanethidine (Ismelin)
  • Isoniazid
  • Ketoconazole (Nizoral)
  • Levodopa (Larodopa, Sinemet)
  • Metoprolol (Lopressor, Toprol XL)
  • Monoamine oxidase (MAO) inhibitors
  • Muscle relaxants
  • Oral contraceptives
  • Parkinson's disease medications
  • Paroxetine (Paxil)
  • Probenecid (Benemid)
  • Propafenone (Rhythmol)
  • Propoxyphene (Darvon)
  • Propranolol (Inderal)
  • Quinidine (Quinidex, Quinaglute)
  • Rifampin (Rifadin)
  • Sedatives, sleeping pills, or tranquilizers
  • Seizure medications
  • Sertraline (Zoloft)
  • Theophylline (Theo-Dur)
  • Valproic acid (Depakene)
Limbitrol Dosage Information: 

Typical Dosage Recommendations

Dosage depends on the patient's health and the condition being treated. Limbitrol is generally prescribed as one tablet taken 3 or 4 times per day.

Missing a Dose of Limbitrol

If you miss a dose of Limbitrol, take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and wait to return to your regular dosing schedule.

Limbitrol Overdose

Seek emergency medical attention if you think you have used too much of this medication, as an overdose or a combination of this medication with alcohol may result in death. Signs of overdose include confusion, sleepiness, lessened reflexes, and coma.

Limbitrol FDA Approval: 

December 23, 1977

Limbitrol Recall/Black Box Warning Information: 

Risk of Suicide/Depression

There is a Black Box warning on Limbitrol regarding a possible increase in suicidal thoughts and behavior noted when the medication is used in children, teenagers, and young adults with depression. Patients who initiate treatment on antidepressants should be carefully monitored for signs of worsening depression, suicidal tendencies, or unusual changes in behavior.

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