Bayer has once again fallen short in its attempt to overturn a significant Roundup verdict.

On Tuesday, the Western District Missouri Court of Appeals upheld a verdict from 2023. The lawsuit awards a combined $611 million to multiple plaintiffs over claims that the popular weed killer is tied to the development of non-Hodgkin lymphoma.

In 2023, the Missouri jury initially awarded $1.56 billion to the plaintiffs, but that payout was later reduced. Bayer had hoped to have the trial result overturned completely on appeal.

Instead, that result stands.

“The overwhelming weight of science as well as the assessments of the EPA and leading health regulators and scientists worldwide support the safety and non-carcinogenicity of Roundup,” the company said in a statement. “We will continue to defend our products in Court.”

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This decision comes amidst a spate of court losses in Roundup lawsuits for Bayer.

Just weeks ago, the Superior Court of Pennsylvania upheld a $175 million verdict from a 2023 trial in a similar case. In March, a Georgia man was awarded more than $2 billion after claiming his cancer was tied to the weed killer.

Tens of thousands of Roundup lawsuits remain active across the country.

Latest Loss Comes as Bayer Weighs New Roundup Settlement

With losses in court continuing, Bayer may seek a new settlement to resolve much of the litigation.

The Wall Street Journal reported earlier this month that Bayer is considering a new Roundup settlement that could involve thousands of cases pending in Missouri state court.

Bayer previously agreed to a settlement worth more than $10 billion in 2020. But it did not cover all lawsuits, and new cases continued to be filed.

The company may also consider moving Monsanto into bankruptcy. Monsanto was acquired by Bayer in 2018 and, as the maker of Roundup, is at the center of many lawsuits.

If the company were to file for Chapter 11, the existing lawsuits would be paused. As part of the bankruptcy process, a settlement would likely be negotiated to resolve all existing cases.