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Statins May Be Beneficial Beyond Cholesterol Control, But Not Without Risks

Statins bottle on pharmacy shelf

Statins prescribed to lower cholesterol may also be beneficial for reducing the risk of a number of other health problems, doctors say.

They point to a new study, published in the July 2013 American Heart Association (AHA) journal Circulation: Cardiovascular Quality and Outcomes that compared several statins for safety and effectiveness. Researchers compared data gathered from trials involving 246,955 individuals. Results revealed that statins also decrease inflammation in the body, in addition to lowering cholesterol.

Statins, sold under such brand names as Crestor, Lipitor, Mevacor and Zocor, are usually prescribed to people with high cholesterol to prevent heart disease. As many as 30 million Americans take statins, and statistics show that they are effective in lowering cholesterol.

Statin use is on the rise in the United States. According to the latest revised cholesterol guidelines, 27 million more Americans should be on statins to prevent heart disease.

However, these drugs remain controversial, and there are still doctors on both sides of the issue.

CBS News medical contributor Holly Phillips said in a CBS News article: “There are cardiologists who feel they should be added to the water supply because they’re so beneficial, and there are people that feel they should be prescribed much less.”

Statins may also reduce inflammation in the body, and some doctors feel that the drugs may also treat diseases caused by inflammation. Phillips said, “”Inflammation is linked to a number of other diseases: Alzheimer’s disease, a number of forms of cancer, strokes. So by lowering that, we could theoretically lower many of these diseases.”

But there are definitely risks, and other doctors are not as eager to jump on the statin bandwagon.

Studies Show Statins May Increase Diabetes Risk

The most publicized side effect of statins like Lipitor is the risk of developing diabetes, a disease already on the rise in the United States.

One of the critics of statins is Dr. Mark Hyman, a practicing physician and best-selling author. In a Huffington Post article, Hyman wrote: “If all doctors followed the latest cholesterol treatment guidelines and all their patients took their prescribed statin medication, there would be 3.5 million more diabetics in America.”

For post-menopausal women, the risk of diabetes is 71 percent higher, according to a study published in the Archives of Internal Medicine. Asian women are at the top of the scale, with a whopping 78 percent increased risk.

Statins are also prescribed to protect against heart attacks, but evidence shows they are not effective in preventing first heart attacks, said Hyman.

He adds that statins may be “an acceptable risk if there were no other treatment for heart disease.”

The risks of statins include:

  • Muscle damage, cramps, weakness
  • Exercise intolerance
  • Sexual dysfunction
  • Liver damage
  • Nerve damage

Some people injured by Lipitor chose to file lawsuits, and the claims are currently pending in the U.S. District Court for the District of South Carolina.

Even the FDA finds the evidence of side effects concerning enough to update side effect information to the drugs’ package inserts.

FDA Adds Diabetes, Memory Loss, Liver and Muscle Injury to Statin Warnings

In 2011, the U.S. Food and Drug Administration (FDA) expanded its advice on statin risks and revised drug safety inserts to reflect its concerns.

The FDA advised patients and doctors that it had received reports of liver injury, memory loss, increased blood sugars that may lead to diabetes, and muscle damage.

On the FDA’s website, the agency’s deputy director for safety in the Division of Metabolism and Endocrinology Products, Amy G. Egan, said, “Their benefit is indisputable, but they need to be taken with care and knowledge of their side effects.”

Last modified: July 12, 2017


Michelle Y. Llamas is a senior content writer and researcher for Drugwatch. She is also the host of the Drugwatch Podcast where she talks to patients, experts and advocates about drugs, medical devices and health. She uses her technical writing experience to provide easy-to-understand information on how drugs and devices work. But she also tells people what happens when products that are supposed to improve their lives can hurt them.

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  1. Davis, Shoshana. (2013, July 13). New wonder drug? Statins may have use beyond cholesterol. CBS News. Retrieved from http://www.cbsnews.com/news/new-wonder-drug-statins-may-have-use-beyond-cholesterol/
  2. U.S. Food and Drug Administration (FDA). (2011, February 27). FDA expands advice on statin risk. Retrieved from http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm293330.htm
  3. Hyman, M. (2012, January 19). Why women should stop their cholesterol lowering medication. Retrieved from http://drhyman.com/blog/2012/01/19/why-women-should-stop-their-cholesterol-lowering-medication/#close