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Total Knee Replacement Increases Hip Fracture Risk

doctor examines a 3d model of a hip bone

People with osteoarthritis may be at increased risk for hip and vertebral fractures in the ten years after a total knee replacement, according to a recent study. The new findings could impact more than 700,000 Americans who get knee replacements each year.

Swedish researchers from Sahlgrenska Academy in Molndal reviewed the medical records of 3,221 people with total knee replacements. Researchers found people who had knee replacement surgery had a four percent increase in hip fracture risk. In addition, they had a 19 percent increase in spinal fractures. Mortality risk also increased after surgery.

Scientists weren’t exactly sure what contributed to the increased risk. But, it could be because of the “increase of physical activity due to rehabilitation, and other biomechanical factors,” said lead study author C. H. Vala.

Other doctors weighed in on the findings, including Dr. Caroline Messer, director of Lennox Hill Hospital’s Center for Pituitary and Neuroendocrine Disorders.

The increase in fractures is most likely because of “improved mobility and activity as a result of the knee replacement surgery,” Messer, a bone loss specialist, told Health Day. “In addition, patients who chose to have the surgery rather than conservative management of osteoarthritis may have been the same individuals who were determined to lead very active and therefore somewhat riskier lifestyles in the future.”

The study was not designed to find a causal relationship between increased fractures and knee replacement, however. Messer said more research is needed to connect the two.

Knee Replacements on the Rise in US

About 50 million people in the U.S. suffer from some form of arthritis and new technology makes getting knee replacement easier. Improved technology also makes complications less common.

A study presented at the 2014 American Academy of Orthopaedic Surgeons (AAOS) looked at data for more than 2 million people who had knee replacement surgery and found the rate jumped 120 percent over a ten year period.

While the majority of patients can expect their knees to last at least 20 years, about 10 percent will need revision surgery, the AAOS said.

“It appears that revision rates are growing in a younger age group, but the value is to focus on understanding why these patients are at increased risk,” Dr. William Robb, director of the Illinois Bone and Joint Institute, a Chicago-area orthopaedic practice, told the Arthritis Foundation.

Along with more knee replacements, revision surgery rates also rose. Experts say there are a number of causes for revision surgery, with infection and implant loosening being the most common.

Faulty Knee Replacements Lead to Lawsuits

Revision surgery can also be necessary when an implant is faulty. Some patients whose knee implants failed early filed lawsuits against knee implant makers, claiming manufacturers failed to warn them of the increased risks.

Manufacturers such as Zimmer, Smith & Nephew, DePuy Orthopaedics and Stryker issued several recalls over the years because of malfunctioning components.

For example, in 2015 the FDA issued a class II recall for Zimmer’s Persona Knee because the company received complaints that the device could loosen early, causing complications.

Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine

3 Cited Research Articles writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our editorial policy to learn more about our process for producing accurate, current and balanced content.

  1. International Osteoporosis Foundation. (2016, April 16). Hip fracture risk rises in the 10 years after total knee replacement. ScienceDaily. Retrieved April 18, 2016 from
  2. Bloom, S. (2015, July 30). Knee and hip replacements on the rise thanks to robotically assisted surgery. Inside Jersey. Retrieved from
  3. Rath, L. (2014). The Risks of Early Knee Replacement Surgery. Retrieved from
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