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Exactech Connexion GXL Hip Liners

Exactech Connexion GXL Hip Liners are hip implants used for primary and revision hip replacement surgery. The liner is made of a type of plastic called polyethylene. Exactech claims they use a special process to make Connexion GXL liners tougher and reduce wear.

Exactech uses irradiated ultra-high-molecular-weight polyethylene (UHMWPE) plastic in its Connexion GXL hip liners, according to the company’s website. Using a special radiation process on the plastic makes the liners more resistant to wear.

While other manufacturers use radiation to reduce wear, this often comes at the cost of fracture toughness. According to Exactech, the compression-molded plastic in its Connexion GXL liners uses a different radiation process.

“This process provides a 59 percent wear reduction over the clinically successful standard Exactech polyethylene while maintaining an acceptable level of fracture toughness,” according to an Exactech brochure.

Connexion GXL hip liners are indicated for use in people who need a total hip replacement because of osteoarthritis, osteonecrosis, rheumatoid arthritis, congenital hip dysplasia, ankylosing spondylitis and other degenerative hip problems.

How They Work

Exactech Connexion GXL hip liners, also called acetabular liners, are one part of a complete hip implant.

In order to recreate the hip joint, implants have a ball that fits into a cup called an acetabular component. The component is made of an acetabular shell and a liner. This ball and cup fit into the hip socket. A stem attaches to the ball and connects to the thighbone.

Acetabular liners fit in between the ball and the acetabular shell. This allows the implant to move. The liners can be made of ceramic or plastic.

Exactech Connexion GXL hip liners are contraindicated in patients with severe infection, patients with neuromuscular disorders that affect the hip joint, and patients whose weight, activity level, or age would cause early failure.


Most people who have hip replacements recover well. Exactech markets the Connexion GXL liner as more resistant to wear and fracture, but some studies have reported osteolysis in patients implanted with the liner.

Osteolysis occurs when debris from polyethylene wear builds up in the joint. It causes the surrounding tissue and bone to degenerate. This can cause implant loosening and lead to premature revision surgery.

Symptoms associated with implant loosening include:
  • Pain
  • Stiffness
  • Difficulty with mobility
  • Joint weakness
Lawsuit Information
Implant loosening and revision surgery are among the injuries named in hip replacement lawsuits. Learn more.
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Exactech’s hip simulator studies showed a 59 percent reduction in the wear rate.

However, two 2020 studies published in peer-reviewed medical journals found that the Exactech Connexion GXL liner may be prone to a high rate of early failure. Study authors concluded the failure rate was caused by high wear rates that led to osteolysis.

High Rate of Early Failure

Dr. W. Christian Thomas and colleagues at the University of Florida College of Medicine published their study findings in the Journal of Arthroplasty.

Authors looked at their institutional database for patients who had significant osteolysis after a primary hip replacement with an Exactech Connexion GXL liner from January 2009 to June 2019.

They identified 12 patients, and nine of them were undergoing revision surgery because of complications. They found the average time before the implants failed was 55.9 months, or about five years.

Authors did not find any patient risk factors or implant positioning, so they concluded it could be the implant’s design causing early failure.

“The Exactech Connexion GXL liner may be prone to a high rate of early failure from wear and severe secondary osteolysis. We recommend close surveillance of patients with this bearing surface,” authors concluded.

‘Catastrophic Early Polyethylene Wear’

Dr. Cynthia Kahlenberg and colleagues at the Hospital for Special Surgery published their review in Arthroplasty Today.

Authors looked at 204 total hip replacements performed by one surgeon using the Exactech Connexion GXL liner. They found five cases of osteolysis and severe wear that occurred within five years of surgery.

All five patients reported hip pain. X-rays found wear with osteolysis in the joints, and MRIs found inflammation.

“This review of 5 cases of catastrophic early polyethylene wear demonstrates a concerning trend with the use of the Exactech Connexion GXL liner,” authors concluded.

They recommended further investigation.

Exatech Connexion GXL Hip Liner
Connexion GXL Hip Liner Facts
  1. Uses Total hip replacement, revision hip replacement
  2. Complications Pain, stiffness, loosening, device failure (and revision surgery), limited range of motion and osteolysis
  3. Manufacturer Exactech, Inc.

Please seek the advice of a medical professional before making health care decisions.

Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine
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  1. Exactech. (2005). Summary of Safety and Effectiveness. Retrieved from
  2. Exactech. (2010). Novation Comprehensive Hip System. Retrieved from
  3. Exactech. (2012). Design Rationale: Connexion GXL Enhanced Polyethylene. Retrieved from
  4. Exactech. (2012). The Dangers of Big Femoral Heads on Thin Polyethylene: The Missing Part of the Equation. Retrieved from
  5. Hospital for Special Surgery. (n.d.). Osteolysis. Retrieved from
  6. Kahlenberg, C.A. et al. (2020). Early failure of a modern moderately cross-linked polyethylene acetabular liner. Retrieved from
  7. Thomas, W.C. et al. (2020). Early Polyethylene Failure in a Modern Total Hip Prosthesis: A Note of Caution. Retrieved from
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