Celexa

Celexa is a prescription antidepressant that increases levels of serotonin, a brain chemical linked to mood, sleep regulation and emotions. It is approved for treating major depression. Off-label uses include treatment of anxiety, obsessive-compulsive and eating disorders and diabetic neuropathy.

*Please seek the advice of a medical professional before discontinuing the use of this drug.

Celexa 10mg Pill

Dosage: 20 mg; up to 40 mg

Used to Treat: Depression and general anxiety disorder

Related Drugs: Lexapro, Paxil, Zoloft, Prozac

Manufacturer: Forest Laboratories

Black Box Warnings: Suicide

FDA Approval: 1998

View Lawsuit Information

Celexa is the brand name of a prescription antidepressant belonging to a family of drugs called selective serotonin reuptake inhibitors (SSRIs).

Like other SSRIs, Celexa works by increasing levels of a brain chemical called serotonin, which is linked to mood, sleep regulation and emotions. Celexa is approved for the treatment of major depression, but is also used off-label to treat anxiety disorders, obsessive-compulsive disorder, eating disorders and diabetic neuropathy.

Celexa 20mg pill
Celexa 40mg pill
Celexa 10mg pill

Celexa comes in three sizes – 10mg, 20mg, and 40mg

Patients who use Celexa can begin to see significant changes in their mood after several weeks. Doctors generally expect to a patient’s condition to improve after a couple of months.

After Forest Laboratories introduced Celexa in 1998, it quickly became one of the most widely used antidepressants in the U.S., with more than 16 million prescriptions written each year. Although Celexa is still prescribed today, sales and use have declined significantly since generic versions of the drug (citalopram) became available. Forest Laboratories’ also introduced a similar drug, Lexapro in 2002, that has also eaten into sales.

Celexa is among the most selective of the SSRI class of antidepressants. Selectivity means the degree to which a dose of a drug produces the desired effect in relation to side effects.

What Should People Know Before Taking Celexa?

Clinical trials have shown Celexa is effective in maintaining an antidepressant response for up to 24 weeks after just six to eight weeks of treatment. But it may take several weeks before symptoms improve after a patient starts taking the drug.

However, doctors who prescribe Celexa should carefully monitor patients on an individual basis. The recommended initial dose of Celexa is 20 mg daily, with an increase to a maximum dose of 40 mg each day. In 2012, the FDA said that Celexa is not recommended at doses greater than 20 mg a day in patients older than 60. Celexa is not approved for use in children and young people who have had suicidal thoughts after first taking it.

To avoid a dangerous drug interaction, people who have used an MAO (monoamine oxidase) inhibitor in the previous two weeks should not take Celexa.

Patients should always consult their doctor before stopping use of Celexa. It is important to work out a plan with your doctor to slowly “step-down” the dosage of any SSRI. Stopping suddenly can result in potentially dangerous withdrawal symptoms.

Suddenly stopping use can result in withdrawal symptoms, including:

  • Dysphoria (profound state of unease or dissatisfaction)
  • Irritability
  • Agitation
  • Dizziness
  • Sensory disturbances
  • Anxiety
  • Confusion
  • Headache
  • Insomnia

Patients should be monitored for these symptoms if they stop treatment.

Celexa is not considered addictive. However, some patients may abuse the drug, taking more than the recommended dosage while trying to elevate their mood.

Physicians should carefully evaluate patients with a history of drug abuse and monitor them for signs of abuse or misuse.

Patients should inform their doctors of any history of these conditions before taking Celexa:

  • Heart conditions
  • Bleeding or clotting disorders
  • Seizures or epilepsy
  • Suicidal thoughts
  • Kidney or liver disease
  • Electrolyte imbalance
  • Bipolar disorder
  • Glaucoma

Common Side Effects of Celexa

The most common side effects of Celexa are nausea and vomiting, increased sweating, dry mouth and headaches. Insomnia and drowsiness are also common, appearing in 15 percent or more of patients in clinical trials.

These side effects are more likely with higher doses, and side effects such as nausea, insomnia and drowsiness are likely to go away once the body adjusts to the medication. As with other SSRIs, men who take Celexa may experience abnormal ejaculation, a decreased libido and erectile dysfunction (impotence).

Celexa is not recommended for patients with heart conditions, low blood sugar (hypoglycemia) or low magnesium in the blood (hypomagnesemia).

Black Box Suicide Warning

Like other SSRIs, Celexa’s label carries a black box warning for an increased risk of suicide. Black box warnings are the strictest warnings the FDA can require for prescription drugs. The agency can require they be added when there is reasonable evidence of a serious hazard.

Antidepressants like Celexa, are required to carry this label due to their ability to increase the risk of suicidal thoughts and behaviors in patients. This risk is heightened in children, adolescents and young adults taking Celexa and other similar drugs used to treat depression, according to short-term studies.

Celexa During Pregnancy, Link to Birth Defects, Autism

Studies link Celexa and other SSRIs to an increased risk of autism and several birth defects when taken during pregnancy.

Despite this, some doctors continue to prescribe Celexa to pregnant women, believing that untreated maternal depression could have even more serious effects.

First-trimester usage of SSRIs is linked to a slight increase in the risk of miscarriage. Studies also suggest that women who take SSRIs during that window may experience premature delivery or a baby with low birth weight. Late-pregnancy SSRI use can lead to withdrawal symptoms in the baby, including seizures, feeding difficulty and behavioral problems like constant crying. These symptoms are typically short-lived.

Celexa and Birth Defects

Celexa and most other SSRIs fall under the FDA’s Class C pregnancy risk. This means they have shown harm to animal fetuses but there are no adequate and well-controlled studies in human fetuses. Medical experts believe the risk of birth defects is low when women take Celexa while pregnant.

FDA Warns of Heart Conditions Related to Celexa

In 2012, the FDA revised health warnings about Celexa regarding the drug’s potential to disrupt normal heart function, especially in those taking higher dosages. Labels are now marked to warn people with heart conditions of this possibility.

QT Syndrome: Celexa increases the risk of Long QT syndrome, a condition that can lead to an abnormal heart rhythm condition called Torsade de Pointes, which can be fatal.

In 2012, the FDA revised approved changes to Celexa’s label to show the drug’s potential to disrupt normal heart function, especially in those taking higher dosages. Labels now warn people with heart conditions of this risk.

Patients with long QT syndrome could be at high risk of serious complications if they take Celexa or generic versions of the drug. But because it may still be beneficial for some of these people to use Celexa, the agency approved label revisions to specifically caution these patients about the dangers.

Label changes include:

  • Recommending discontinuation of Celexa in patients with persistent QTc measurements greater than 500 milliseconds. QT intervals measure the amount of time between waves of the heart’s electrical cycle.
  • ECG monitoring in Celexa patients at high risk of QT prolongation.
  • The maximum recommended dose of 20 mg per day for patients 60 years of age or older.

In the label revisions, the FDA advises patients currently taking a dose greater than 40 mg per day to consult their doctor. The label revisions advised patients taking a dose greater than 40 mg per day to consult with their health care professional and to seek immediate care if they experience an irregular heartbeat, shortness of breath, dizziness or fainting while taking Celexa.

Other Potential Serious Side Effects of Celexa

Other potential side effects associated with Celexa that may require emergency medical attention include serotonin syndrome and allergic reactions.

Serotonin syndrome is a potentially fatal condition that occurs when there is too much serotonin in the brain. This generally occurs when two drugs that increase serotonin levels are taken together. Symptoms can include changes in mental condition (agitation or hallucinations), coma, muscle twitching, racing heartbeat, changes in blood pressure, fever, nausea or diarrhea, and stiff muscles.

MAOI Risk Celexa patients taking monoamine oxidase inhibitors (MAOIs) have an increased risk of serotonin syndrome.

Severe allergic reactions can be fatal. People allergic to Celexa may experience trouble breathing, facial swelling, or itchy welts or hives, accompanied by a fever and joint pain. People who have allergic reactions to Celexa should seek medical attention right away.

Author

Terry Turner is an Emmy-winning, former television journalist. He is an associate member of the American Bar Association, the ABA’s Health Law group and a member of the Alliance of Professional Health Advocates. He holds six certificates in Health Literacy for Healthcare Professionals from the Centers for Disease Control and Prevention. As a Washington-based investigative reporter, he routinely reported on health and medical policy issues before Congress, the FDA and other federal agencies. Terry received his B.A. in Media Arts from Lyon College.


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