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Stevens-Johnson Syndrome

Stevens-Johnson syndrome (SJS) is a rare, potentially fatal skin disease that causes flu-like symptoms and a blistering, painful skin rash that makes skin peel. It’s most often caused by medications but may also be caused by infections. Treatment typically requires hospitalization, medication to treat infections and supportive care.

Man with flu smyptoms in hospital bed

Stevens-Johnson syndrome is a hypersensitivity reaction. This means the immune system overreacts, causing inflammation, skin rashes and other symptoms, but it’s not contagious. SJS may also be called erythema multiforme major and is often grouped together with toxic epidermal necrolysis (TEN), which is a similar condition with more severe symptoms.

SJS is rare, and it affects about one to two million people each year, according to the U.S. Library of Medicine. People of all ages can get SJS.

It typically starts within one to three weeks after taking a drug. The chance of dying from this disease is about ten percent, while up to 50 percent of people with TEN may die. People who survive the disease may take weeks or months to recover.

This disease is a medical emergency, and people who notice symptoms should seek medical care immediately.

Stevens Johnson Syndrome Fast Facts
Source: U.S. National Library of Medicine


The first symptoms of SJS start around one to three weeks after taking a drug and include headache, cough, fever, body aches and inflammation in the eyes.

A few days after these flu-like symptoms, people with SJS develop a flat red rash on the face, trunk and neck that spreads to the rest of the body and begins to blister. SJS rash affects up to 10 percent of the body’s surface.

The painful rash spreads to the mouth, throat, eyes, genitals and anus. It makes it difficult to urinate and swallow. If it affects the digestive and respiratory tract, people may have diarrhea and difficulty breathing.

Symptoms of SJS include:
  • Blistering, peeling rash with sores on the skin
  • Blisters and sores on mucus membranes of the throat, mouth, eyes, anus and genitals
  • Blisters and swelling causing eyes to crust shut
  • Body aches
  • Cough
  • Fever
  • Painful mouth that is difficult to close and may cause drooling
  • Painful urination from blistered mucous membranes


SJS affects the skin and mucous membranes and it may lead to other health problems. The most severe complication is death.

SJS complications include:
  • Dangerous loss of fluids through damaged skin
  • Eye problems
  • Uneven skin color after regrowth of skin
  • Problems with internal organs such as the heart, lungs, liver, kidneys and esophagus
  • Multi-organ failure
  • Skin infections that can lead to sepsis (blood poisoning)
  • Death


Reactions to medications and infections are the causes of SJS.

Drug reactions are the most common cause in adults, and about 60 percent of cases can be linked to certain medications, according to an article published in U.S. Pharmacist by Melissa A. Ruminski and colleagues. In fact, researchers have identified more than 100 drugs that could trigger SJS.


The highest risk drugs include anticonvulsants, anti-gout medications and some nonsteroidal anti-inflammatory drugs (NSAIDs). The anticonvulsant Lamictal has a black box warning for the risk of SJS and other serious rashes.

Common drugs linked to SJS include:
  • Antigout: Zyloprim (allopurinol)
  • Antibiotics: sulfonamides, penicillins, fluoroquinolones, tetracyclines, macrolides
  • Anticonvulsants: Lamictal (lamotrigine), Tegretol (carbamazepine), Dilantin (phenytoin), Depakote (valproate)
  • Antiretrovirals: Viramune (nevirapine)
  • Pain Relievers: NSAIDs (ibuprofen, diclofenac meloxicam), Tylenol (acetaminophen)
SJS Linked to Provigil & Nuvigil
In rare cases, wakefulness drugs Provigil and Nuvigil can cause potentially fatal skin rashes, including Stevens-Johnson Syndrome. Learn more.
View Side Effects


Viral infections are more likely to cause SJS in children, but adults may also get the disease from an infection. Although less common, bacterial infections may also trigger a reaction.

Infections linked to SJS include:
  • Coxsackie virus
  • Epstein-Barr virus
  • Flu
  • Herpes-simplex virus
  • Mumps
  • Pneumonia

Risk Factors

Some factors can increase a person’s risk for SJS. These include genetics and having other health conditions.

Risk factors include:
  • Autoimmune diseases (psoriasis, rheumatoid arthritis and others)
  • Bone marrow transplant
  • Females are more likely to get it than males
  • Genetics – specific human leukocyte antigens (HLAs)
  • HIV
  • Organ transplant
  • Previous history of SJS
  • Systemic lupus erythematosus
  • Weakened immune system

Diagnosis & Treatment

There is no specific test for SJS. In order to diagnose it, medical providers will ask questions, take blood samples, do a skin biopsy and examine the rash.

Most people with SJS end up in the hospital for treatment. Doctors will look at any drugs that may have caused the reaction and stop the medication. Because of the extent of skin damage, some people may be treated in the burn unit of the hospital and receive special care to prevent infections.

Sometimes, a patient may receive a plasma exchange. A plasma exchange involves removing blood and separating the plasma from the blood cells and platelets. The theory is that this treatment may remove the drug or antibodies that could be causing the reaction.

Once the drug that has been causing the reaction has stopped or the infection that triggered the reaction is treated, the rash will go away. After a few days, new skin will grow.

Treatment for SJS focuses on controlling symptoms and making the patient comfortable. It may include:
  • Antiseptic, anesthetic mouthwashes to relieve mouth pain
  • Cool, moist compresses
  • Corticosteroids to control skin inflammation
  • Eye ointments or drops for eye symptoms
  • Fluids and nutrition passed through a nasogastric tube, a tube that goes to your stomach through the nose
  • Painkillers to help soothe the pain of raw skin
  • Removing dead skin and applying dressings
  • Unscented lotions to moisturize and calm skin

Recovering from SJS

The severity of the reaction determines how long it will take to recover. Even after the reaction stops, it can take weeks or months to recover, and fatigue after leaving the hospital may last for weeks.

People who survive SJS or TEN may have long lasting complications. These include dry, discolored skin, hair loss, excessive sweating and loss of fingernails and toenails.

Some people may also have impaired taste, genital abnormalities, problems urinating and chronic dry eyes which may increase sensitivity to light and impair vision.

Make sure you talk to your doctor about how to avoid the medication that caused the reaction and medicines similar to it. After you’ve had SJS, you have an increased risk of developing it in the future.

There is no way to prevent it, but you can make sure you don’t expose yourself to medication that could trigger a reaction. Make sure you talk to your doctor about any medications before starting them.

Please seek the advice of a medical professional before making health care decisions.

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Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine
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6 Cited Research Articles writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our editorial policy to learn more about our process for producing accurate, current and balanced content.

  1. Cleveland Clinic. (n.d.). Stevens-Johnson Syndrome. Retrieved from
  2. Ergen, E.N. & Hughey, L.C. (2017). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Retrieved from
  3. Gonzalez, M.E. (2018). Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Retrieved from
  4. National Health Service. (n.d.). Stevens-Johnson syndrome. Retrieved from
  5. Ruminski, M.A. et al. (2013, July 17). Stevens-Johnson Syndrome: What a Pharmacist Should Know. Retrieved from
  6. U.S. National Library of Medicine. (n.d.). Stevens-Johnson syndrome/toxic epidermal necrolysis. Retrieved from
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