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Big Pharma and Medical Device Manufacturers

Big Pharma is a term used to refer to the global pharmaceutical industry. It also includes the trade group, Pharmaceutical Research and Manufacturers of America (PhRMA). Big Pharma and medical device companies make billions of dollars every year. They’ve also spent billions on fines, settlements and jury verdicts.

Last Modified: February 5, 2024
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Big Pharma is one of the most powerful industries in the world. The global revenue for pharmaceuticals was over $1.42 trillion in 2021. But nowhere else in the world do the drug and medical device industries have as much power and make as much money as in the U.S.

Six of the top 10 pharmaceutical companies in 2017 had their headquarters in the U.S. These include Johnson & Johnson, Pfizer, Merck, Gilead, Amgen and AbbVie.

But only 28 percent of Americans have a good opinion of Big Pharma. In fact, Big Pharma is the second most hated industry in America. It’s right behind the tobacco industry and the oil, gas and chemical industry.

Big Pharma is also the biggest defrauder of the Federal Government under the False Claims Act, according to consumer watchdog group Public Citizen.

The industry has a history of fraud, bribery, lawsuits and scandals. Despite criminal charges and fines, Big Pharma companies continue to do business.

What Is Big Pharma?

Big Pharma is a term for the world’s largest publicly traded pharmaceutical companies.

The biggest drug companies may also have subsidiaries that manufacture medical devices. Medical devices can be anything from syringes to hip and knee implants.

Prescription drugs and devices manufactured by these companies bring in billions in profits.

Pharmaceutical companies are usually larger than companies that focus on medical devices alone. Drug companies also tend to make more money.

Top Big Pharma Companies By Sales

Company2017 Total Revenue from Pharmaceutical Products (in billions) 2017 Total Revenue (in billions)Popular Prescription Products
Pfizer (U.S.)$52.5$52.5Eliquis, Nexium, Lipitor, Celebrex, Lyrica, EpiPen, Viagra, Xeljanz, Zoloft, Zithromax
Roche (Switzerland)$44.4$57.4Actemra, Tamiflu, Valium
Sanofi (France)$36.7$42.9Zantac, Ambien, Dupixent, Lantus, Lemtrada, Plavix, Synvisc-One, Taxotere
Johnson & Johnson (U.S.)$36.3$76.5Elmiron, Tylenol, Fentanyl, Haldol, Risperdal, Invokana, Invokamet, Levaquin, Lexapro, Remicade, Stelara, Topamax, Xarelto
Merck & Co. (U.S.)$35.4$40.1Belsomra, Cozaar, Fosamax, Gardasil, Januvia, Keytruda, Nasonex, NuvaRing, Propecia, Singulair, Zostavax
Novartis (Switzerland)$33.0$49.1Cosentyx, Diovan, Entresto, Exforge (valsartan), Ritalin, Tasigna, Volatren, Xolair
AbbVie (U.S.)$28.2$28.2AndroGel, Depakote, Humira
Gilead Sciences (U.S.)$25.7$25.7Atripla, Biktarvy, Descovy, Truvada, Harvoni, Tamiflu
GlaxoSmithKline (GSK) (U.K.)$24.0$42.1Advair, Avandia, Flonase, Levitra, Lamictal, Prolia, Wellbutrin, Valtrex, Zyban
Amgen (U.S.)$22.8$22.8Enbrel, Otezla, Repatha, Prolia

Top Medical Devices Companies

CompanyHeadquartersFeatured Medical Devices
MedtronicDublin, IrelandBone grafting, hernia repair
Johnson & JohnsonNew Brunswick, New JerseyHip and knee implants, surgical mesh, power morcellators
GE HealthcareLittle Chalfont, United KingdomUltrasound machines, MRIs, CT scanners, ventilators
Philips (Healthcare)Amsterdam, NetherlandsUltrasound machines, CT scanners, mammogram machines, X-ray machines
Siemens (Healthineers)Munich, GermanyHearing aids, diabetes testing products, diagnostic machines
StrykerKalamazoo, MichiganHip and knee implants, hospital beds
Baxter InternationalDeerfield, IllinoisSurgery products, dialysis machines, hospital devices
RocheBasel, SwitzerlandDiabetes testing products, cancer screening devices, research equipment
Abbott LaboratoriesChicago, IllinoisCatheters, stents, surgical guidewires
Boston ScientificMarlborough, MassachusettsIVC filters, surgical mesh

Big Pharma Net Worth

By 2021, Big Pharma profits for prescription drugs are expected to reach $610 billion.

Medical devices are also lucrative. The U.S. makes about $148 billion, according to the U.S. Department of Commerce. That’s about half of the world’s share of the market.

American Prescription Drug Spending
Americans spent $457 billion on prescription drugs in 2015. Drug prices continue to rise.

Americans spent an all-time high of $457 billion on prescription drugs in 2015. And drug prices continue to rise.

Consulting firm Segal Consulting expects drug prices to rise 11.6 percent in 2017. This estimate is for Americans under the age of 65.

In contrast, wages are only expected to rise 2.5 percent. This means many Americans won’t be able to afford their medications.

Who Owns Big Pharma?

Well, the better question is: Who does Big Pharma own?

Big Pharma contributes heavily to the annual budget of the U.S. Food and Drug Administration. Big Pharma does this through application fees (user fees) for its new products.

Experts say the industry contributes about two thirds of the FDA’s budget.

Big Pharma also uses its profits and an army of 1,378 paid lobbyists to spread its influence on Capitol Hill.

Big Pharma Spending
For every $1 spent on “basic research,” Big Pharma spends $19 on promotions and advertising.
Source: BMJ

From 1998 to 2016, Big Pharma spent nearly $3.5 billion on lobbying expenses — more than any other industry.

In 2016 alone, it spent about $246 million. That’s more than the defense industries and corporate business lobbyists combined.

Medical device manufacturers also have a lobbying group. Medical Device Manufacturers Association contributed $1.2 million in lobbying funds in 2016.

Its efforts concentrate on medical-device-friendly bills in Congress. They mostly relate to how companies pay taxes.

Critics say Big Pharma relies on manipulative tactics to increase sales. They say it uses expensive advertising to sway lawmakers, FDA and the public.

Notable Big Pharma Scandals

The long road to a Vioxx recall is arguably one of the most notable Big Pharma scandals in U.S. history.

Merck announced a voluntary worldwide recall of its painkiller in 2004. It came four years after evidence linked the drug to significant health risks.

The company’s executives decided not to study Vioxx’s cardiovascular risks. The FDA later found the drug may cause an increased risk of heart attack and stroke.

The US Department of Justice building
Merck paid the U.S. Department of Justice $950 million to resolve criminal charges related to the marketing and sales of Vioxx.

One agency scientist, Dr. David Graham, estimated that the use of Vioxx may have contributed to more than 27,000 heart attacks or deaths.

Both Merck and the FDA came under Congressional scrutiny.

In 2011, Merck pleaded guilty to criminal charges related to the marketing and sales of Vioxx. The company agreed to pay the U.S. Department of Justice $950 million to resolve its misconduct.

Merck settled with tens of thousands of injured patients in 2007. Merck agreed to pay $4.85 billion to plaintiffs and their families.

Top Big Pharma Lawsuit Verdicts and Settlements

In a 24-year period, Big Pharma companies paid 373 settlements for marketing fraud. The settlements totaled $35.7 billion.

Public Citizen published this data in 2013. It called its report Pharmaceutical Industry Settlements: 1991 through 2015.

In 2012, GlaxoSmithKline (GSK) agreed to a $3 billion settlement. It was the largest health care fraud settlement in U.S. history.

The charges stemmed from certain prescription drugs, including Paxil, Wellbutrin and Avandia. GSK still ranks in the top ten for its pharmaceutical drug profits.

Johnson & Johnson is the world’s largest health care company. It paid $2.2 billion in 2013 for improperly marketing its drug Risperdal.

Big Pharma companies were also hit with million- and billion-dollar verdicts. These verdicts rarely impact the companies’ profits.

A jury ordered Takeda Pharmaceuticals and Eli Lilly to pay $9 billion in 2014. The award went to an Actos user who developed bladder cancer.

Takeda still reported an underlying revenue growth of 6.7 percent in 2017. Eli Lilly saw sales of $22.87 billion the same year.

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Talcum Powder Settlements and Verdicts

Johnson & Johnson faces nearly 20,500 federal talcum powder lawsuits and many more in state courts alleging Johnson’s Baby Powder and its other talc products led to ovarian cancer, according to the September 15, 2020 MDL statistics report from the U.S. Judicial Panel on Multidistrict Litigation.

Plaintiffs have been awarded billions in jury verdicts, though some have been overturned. A St. Louis jury awarded $4.69 billion to 22 women, and this remains the largest single verdict so far.

Johnson & Johnson announced it would stop selling its talcum powder products in the Unites States and Canada in May 2020.

Billions in Hip Implant Settlements

Companies have paid billions in hip implant lawsuit settlements to people who claim they were injured by metal-on-metal hip implants.

The largest settlement came from DePuy, a Johnson & Johnson company. The implant maker paid about $4 billion to settle 8,000 ASR hip claims in 2013.

Bayer Settles Essure Lawsuits

In August 2020, Bayer agreed to pay $1.6 billion to resolve about 90 percent of 39,000 Essure birth control claims. Bayer stopped selling the device in December 2018, but providers could still implant Essure up to one year from the device’s purchase date.

Please seek the advice of a medical professional before making health care decisions.