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Study: PPI Acid Reflux Drugs Overused in People with GI Bleeds

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More than half of patients with gastrointestinal (GI) bleeding receive acid reflux drugs called proton pump inhibitors (PPIs) even when guidelines discourage their use, according to a study.

University of Chicago researchers found as many as 65 percent of patients admitted to hospitals with upper GI bleeding receive IV infusions of PPIs such as Nexium (esomerazole) or Prilosec (omeprazole) even when their use is discouraged.

The inappropriate use of PPI drips increases the cost and decreases patient comfort and mobility, the study found. Researchers presented their findings at the 2016 Digestive Disease Week. They also created a system to warn about improper use of therapy.

“Our primary aim was really to promote the appropriate use of PPI drips in upper GI bleedings, since we saw such high numbers of inappropriate use,” Dr. Emmanuel Coronel, lead study author and gastroenterology fellow at the University of Chicago Medicine, told Gastroenterology & Endoscopy News.

Some patients with a low-risk ulcer or another type of lesion causing upper GI bleeding should receive an oral PPI drug or an intermittent dose instead of a continuous IV, researchers said. After following researchers’ guidelines, the inappropriate use of PPI drips dropped. Annual savings were estimated at $93,000.

PPI drugs are some of the most commonly used medications in the U.S. About 20 million Americans take these acid-reducing drugs and spend $14 billion on them each year.

Some experts feel they are overused, and new studies show long-term use of PPIs can lead to a number of side effects. In fact, a San Francisco Department of Public Health study estimated 60 to 70 percent of people who take PPIs would benefit more from lifestyle changes and antacids.

In 2010, the U.S. Food and Drug Administration warned that these drugs can lead to increased risk of bone fracture and infections. Some studies even link the medications to an increased risk of heart attack.

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PPIs Linked to Kidney Damage

In addition to the warnings released by the FDA, studies also link PPIs to an increased risk of kidney damage. In fact, a study published in 2015 in the Pharmaceutical Journal revealed, “All PPIs are associated with acute interstitial nephritis.”

Data from studies continues to show a link between PPIs and kidney disease and damage.

For example, a study published in a 2016 JAMA journal showed PPI users had a 15.9 percent risk of developing kidney disease over 10 years. People with kidney disease were also twice as likely to have used a PPI in the past, according to a study published by BMC Nephrology in 2013.

PPI Side Effects Lead to Lawsuits

The link between kidney injuries and PPIs led to a number of patients filing lawsuits against the drug’s makers.

In June 2016, Terry Buzbee filed suit against AstraZeneca and Takeda Pharmaceuticals after he said Nexium and Prevacid caused his acute kidney injury. According to Buzbee’s complaint, “defendants concealed knowledge of Nexium and Prevacid’s defects, from Plaintiff, the FDA the public in general and/or the medical community specifically.”

Buzbee used Nexium and Prevacid for about 10 years and suffered acute kidney injury that required hospitalization and caused permanent injury, the court documents said.

Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine

2 Cited Research Articles writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our editorial policy to learn more about our process for producing accurate, current and balanced content.

  1. Gastroenterology & Endoscopy News. (2016, August 15). Study Promotes Appropriate Use of PPI Drips for GI Bleeding. Retrieved from
  2. Buzbee v. AstraZeneca et al. (2016, June 13). Complaint and Demand for Jury Trial. Case 1:16-cv-02934-ARR-CLP
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