ALERT: Your health is top priority. We’re committed to providing reliable COVID-19 resources to keep you informed and safe.

Drugs Like Prilosec & Nexium May Damage Arteries

Purple Nexium Pills

New research suggests that popular heartburn drugs called proton pump inhibitors (PPIs) such as Prevacid (lansoprazole), Prilosec (omeprazole) and Nexium (esomeprazole) may damage arteries leading to an increased risk of heart attack, kidney failure and dementia.

In the 2016 study published in Circulation Research, John P. Cooke and colleagues at the Houston Methodist Research Institute exposed endothelial cells — the cells that line the walls of arteries — to Nexium for the clinical equivalent of months or years. They compared the results of those cells to those exposed to another class of heartburn medications called H2 blockers, which includes Zantac (ranitidine).

Are you suffering from complications after taking a PPI? Get a Free Case Review

What scientists found was shocking. While the cells exposed to the H2 blocker showed no signs of aging, the cells exposed to Nexium had a “fried egg” look. Because PPIs inhibit acid production by impairing parts of cells called lysosomes, “garbage” builds up in the artery cells and causes them to age.

The researchers found that vascular cells couldn’t divide or proliferate as well. This made it difficult for cells to repair wounds in blood vessels. This prevents them from performing tasks that prevent heart attack and stroke, like producing a coating that prevents plaque from sticking to vessel walls.

“They start to convert from Teflon to something more like Velcro,” Cooke told the Chicago Tribune. “Things begin to stick.”

Aging Cells Also Linked to Dementia, Renal Failure and Cancer

“I’m perplexed that the pharmaceutical industry didn’t run across this first,” Cooke told “This is something that should have been apparent a long time ago and should have been investigated.”

Cooke said the cells exposed to Nexium also showed signs of shortening in chromosomes tips called telomeres. Previous studies linked shortened telomeres to age-related conditions such as dementia, cancer and cardiovascular disease.

“Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure,” Cooke told the Tribune.

In a previous 2015 study published in PLOS One, Cooke and co-author Nick Leeper connected PPIs to an increased risk of heart attack.

Drug Maker Defends Nexium

Nexium’s maker, AstraZeneca, criticized the study. The study was not conducted “in humans within a controlled clinical trial. Therefore, conclusions around cause and effect cannot be made. Patient safety is an important priority for AstraZeneca and we believe all of our PPI medicines are generally safe and effective when used in accordance with the label,” The Big Pharma giant told The Chicago Tribune.

According to Cooke, one of the problems is people who use PPIs rarely use them in accordance with U.S. Food and Drug Administration Guidelines. The FDA approved these drugs for use only for four weeks at a time, three times a year. Instead, many heartburn sufferers take these drugs long-term.

FDA Warns PPIs Cause Fractures

Cardiovascular problems are not the only concerns with long-term PPI use. As early as 2010, the FDA released warning that these drugs may increase the risk of fracture, cause low levels of magnesium and even contribute to bacteria-induced diarrhea.

People who took the drugs are also filing lawsuits against PPI drug makers. One man sued AstraZeneca after he suffered kidney failure he said Nexium caused. He had to get a kidney transplant and said the company failed to warn the public.

While more studies are needed, the data from Cooke’s study gives experts pause in prescribing or recommending PPIs.

“Bottom line: If you take a daily PPI, which can save lives in the right scenario, check with your doctor and see if you really need it,” Dr. David Robbins, interim chief of gastroenterology at Lenox Hill Hospital in New York City told the Tribune.

Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for nearly a decade. She focuses on various medical conditions, health policy, COVID-19, LGBTQ health, mental health and women’s health issues. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • Member of American Medical Writers Association (AMWA) and former Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine

4 Cited Research Articles writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our editorial policy to learn more about our process for producing accurate, current and balanced content.

  1. Shah, N.H. et al. (2015). Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population. Retrieved from
  2. Thompson, D. (2016). Study: PPI heartburn medication may hurt arteries, putting heart at risk. Retrieved from
  3. Carstensen, M. (2016). Study suggests why common heartburn drugs increase risk for dementia, heart disease. Retrieved from
  4. Yepuri, G. et al. (2016). Proton Pump Inhibitors Accelerate Endothelial Senescence. Retrieved from
View All Sources
Call to speak with a legal expert
Who Am I Calling?

Calling this number connects you with one of Drugwatch's trusted legal partners. A law firm representative will review your case for free.

Drugwatch's sponsors support the organization’s mission to keep people safe from dangerous drugs and medical devices. For more information, visit our sponsors page.

(866) 587-0279