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Prednisone

Prednisone is a prescription corticosteroid that works by lowering inflammation in the body and suppressing the immune system. Prednisone treats several conditions such as skin problems, allergies, arthritis, lupus, ulcerative colitis, leukemia, gastrointestinal diseases and lung problems such as asthma.

Prednisone
Prednisone Facts
  1. Used to Treat Arthritis, severe allergic reactions, multiple sclerosis, lupus, certain lung diseases, certain skin problems, some eye problems, gastrointestinal diseases, blood disorders and inflammatory disorders.
  2. Initial FDA Approval 1955
  3. Related Drugs Dexamethasone, methylprednisolone, hydrocortisone, prednisolone, cortisone

The U.S. Food and Drug Administration first approved prednisone in 1955 for treating rheumatoid arthritis. Since then, health care providers have prescribed it to millions of Americans.

Prednisone is available as an oral tablet in delayed-release and regular formulas. It’s also available in an oral liquid. The drug is available in generic form and under the following brand names: Deltasone, Prednicot, predniSONE Intensol, Rayos, Sterapred and Sterapred DS.

Prednisone is a synthetic glucocorticoid, a natural hormone produced in the adrenal glands. It replaces low levels of steroids in the body. Glucocorticoids are potent anti-inflammatories that reduce redness and swelling. They also suppress the immune system.

The most common prednisone side effects include alteration in glucose tolerance (high blood sugar), fluid retention, rise in blood pressure, increased appetite, behavioral and mood changes and weight gain. These are more common in patients receiving larger doses or who are on long-term therapy.

What Does Prednisone Treat?

Health care providers use prednisone to treat a wide variety of conditions caused by inflammation and overactive immune systems. The drug may not cure a condition, but it can help manage symptoms.

For example, in clinical trials on patients with rheumatoid arthritis, patients who took delayed-release prednisone saw a decrease in duration of morning stiffness. Patients who took prednisone had 46 minutes of morning stiffness versus 85 minutes in people who took a placebo, according to the Rayos drug label.

People with severe asthma or allergies also depend on prednisone. About 30 percent of people with severe asthma require long-term use of oral corticosteroids including prednisone. It remains the only effective treatment to lessen the frequency of severe attacks, according to researchers J. Michael Ramsahai and Peter A.B. Wark’s published article in The Medical Journal of Australia.

Prednisone treats many conditions, including:
  • Acquired (autoimmune) hemolytic anemia
  • Acute leukemia
  • Acute or chronic solid organ rejection
  • Aggressive lymphomas
  • Allergic conjunctivitis
  • Atopic dermatitis
  • Bronchial asthma
  • Contact dermatitis
  • Crohn’s disease
  • Drug sensitivity reactions
  • Fulminating or disseminated pulmonary tuberculosis
  • Herpes zoster ophthalmicus (painful rash in the eye)
  • Multiple sclerosis
  • Nonsuppurative thyroiditis
  • Post-traumatic osteoarthritis
  • Psoriatic arthritis
  • Rheumatoid arthritis
  • Seasonal or perennial allergic rhinitis (inflammation of mucous membranes in the nose)
  • Severe erythema multiforme (Stevens-Johnson syndrome)
  • Systemic lupus erythematosus
  • Tuberculous meningitis
  • Ulcerative colitis
  • Vasculitis

The FDA approved prednisone to treat many of these conditions, but sometimes health care providers prescribe it for off-label uses not approved by the FDA. For example, one such off-label use is to treat chronic obstructive pulmonary disease, or COPD.

How to Use This Medication

Prednisone immediate-release tablets are available in five strengths: 1 mg, 2.5 mg, 5 mg, 10 mg and 20 mg. Delayed-release tablets are available in three strengths: 1 mg, 2 mg, and 5 mg.

Each person’s prednisone dosage varies depending on the condition being treated and how the patient responds to the dose. There are no set dosages on the drug label because they have to be tailored to each patient. The initial dose varies from 5 mg to 60 mg once a day.

Prednisone works best when taken in the morning before 9 am with food or milk. Some patients may need antacids between meals to avoid peptic ulcers when taking large doses.

Patients should swallow tablets whole and shouldn’t chew, break or divide them.

Recommended Dosages
Initial doses of prednisone vary from 5 mg to 60 mg per day depending on the condition being treated and individual patient response.

The drug label provides one recommended dosage to treat acute exacerbations of multiple sclerosis. Patients may take 200 mg per day for one week followed by 80 mg every other day for one month.

Health care providers may increase or lower the dose based on response. After the health care provider finds a dose that works, they will lower it by small increments until the lowest effective dose is reached.

In some cases, providers may recommend taking larger doses every other morning. Patients should not do this without a provider’s recommendation.

When patients are ready to stop therapy, providers slowly wean them off the drug. Stopping the drug suddenly can lead to withdrawal.

How Long Does Prednisone Stay in Your System?

Prednisone has a half-life of about 2 to 3 hours, according to the Rayos drug insert, though other studies place its half-life closer to 3 to 4 hours. Half-life is the amount of time it takes drug level in the body to be 50 percent of what it was when a person first took it.

For example, if a person took 5 mg of prednisone, the dose remaining in the body after three hours would be about 2.5 mg.

It takes about seven half-lives for a drug to leave the body. So based on a half-life time of 2 to 3 hours, it would take 14 to 21 hours for prednisone to leave the body. This is just an average and may be different depending on a person’s age, weight and general health.

Overdose

The chance of dying from prednisone overdose is low and some people may have no symptoms, but others may have life-threatening symptoms. People have died from an overdose.

Symptoms of prednisone overdose include:
  • Abdominal pain
  • Dizziness
  • Drowsiness
  • Headache
  • Nausea
  • Nystagmus (involuntary movements of the eyes)
  • Ringing in the ears
  • Vomiting

Who Shouldn’t Use Prednisone

People who are allergic to prednisone or have a systemic fungal infection should not use this drug.

Patients receiving immunosuppressive doses of prednisone should not receive live or live-attenuated vaccines. Inactivated vaccines may be used, but the patient’s response to these vaccines is unpredictable.

Doctors should monitor patients for allergic reactions and adverse events.

Pregnancy and Breastfeeding

Human and animal studies have shown that prednisone can harm an unborn baby when taken during pregnancy, according to the drug’s label.

Some studies have shown a small increase in the risk of cleft palate and other orofacial clefts when prednisone is taken during the first trimester. There are also reports of decreased birth weight and intrauterine growth restriction — a condition where the baby doesn’t grow at the right rate during pregnancy.

Prednisone can travel to the baby through breast milk, but there haven’t been any reports of adverse events. But high doses of prednisone used for long periods could potentially cause growth problems in breastfed infants.

Drug Interactions and Warnings

Prednisone interacts with a long list of drugs and substances. This isn’t a complete list of all possible drug interactions. Patients should tell their health care provider about all the medicines they take and may start taking.

Prednisone and Alcohol

There are no specific warnings about drinking alcohol with prednisone listed on the drug’s label. But according to the UK’s National Health Service, drinking alcohol with prednisone may increase the risk of upsetting the stomach.

Cytadren, Elipten, Orimeten (aminoglutethimide)

These hormone therapy drugs may stop corticosteroid-induced adrenal suppression when used with prednisone.

Abelcet and Ambisome (amphotericin B injection)

There have been reports that using these drugs with hydrocortisone, a corticosteroid similar to prednisone, may increase risk of congestive heart failure and cardiac enlargement.

Aricept (donepezil), Reminyl (galantamine), Exelon (rivastigmine) and Other Anticholinesterase Agents

Using these drugs with prednisone may cause severe weakness in patients with myasthenia gravis. Providers should have patients stop anticholinesterase therapy at least 24 hours before starting prednisone, if possible.

Warfarin

Using warfarin with prednisone may cause warfarin not to work as well. Providers should monitor patients frequently to make sure the anticoagulation effect is working.

Diabetes Drugs

Prednisone can increase blood sugar levels. People taking diabetes medications may need increased doses.

Antibiotics for Tuberculosis

Isoniazid may not work as well when taken with prednisone.

Phenytoin, Barbiturates, Rifampin, Carbamazepine and other CYP 3A4 Inducers

These drugs may enhance prednisone metabolism. Providers may need to increase the dose of prednisone.

Macrolide Antibiotics, Ketoconazole and other CYP 3A4 Inhibitors

Ketoconazole may cause certain corticosteroids to linger in the body longer. Ketoconazole can decrease drug metabolism by as much as 60 percent. This can increase the risk of corticosteroid side effects.

Cholestyramine

Clearance of corticosteroids — the rate at which the drug is processed and leaves the body — is increased with this cholestyramine.

Cyclosporine

Using prednisone with cyclosporine may cause convulsions.

Lanoxin and Other Digitalis Glycosides

Patients on digitalis glycosides — drugs used for congestive heart failure — may be at increased risk of low potassium levels or hypokalemia. This can lead to heart rhythm problems.

Estrogen Drugs and Oral Contraceptives

Drugs with estrogens such as birth control pills may decrease the metabolism of the drug in the liver and increase the effect of corticosteroids.

Certain Pain Relievers

Using nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen and salicylates such as aspirin may increase the risk of toxicity and gastrointestinal side effects when taken with corticosteroids.

Diuretics and other Potassium-Depleting Agents

Using corticosteroids with diuretics and other potassium-depleting medications may increase the risk of low potassium levels, or hypokalemia.

Skin Tests

Taking prednisone while having a skin test may suppress reactions to the test.

Live or Live-Attenuated Vaccines

People taking prednisone should stop taking the drug before receiving a live or live-attenuated vaccine. Prednisone may increase the replication of some organisms in live-attenuated vaccines. Patients receiving immunosuppressive doses should not use live or live-attenuated vaccines.

Prednisolone vs. Prednisone

Prednisolone and prednisone are both corticosteroids. They work the same way in the body, treat the same health conditions and have similar side effects.

Prednisone is converted into prednisolone in the liver before it can work. Prednisolone’s half-life is also slightly shorter, meaning it is eliminated from the body a little more quickly.

Prednisone is slightly less bioavailable (about 20 percent less) than prednisolone, which means it is slightly less absorbable into the body than prednisolone. Researchers think this is because some people may absorb it differently than others, especially since prednisone has to be converted to prednisolone in the liver. For this reason, some researchers recommend using prednisolone versus prednisone in people with active liver disease.

Prednisolone half-life changes with age. Children process the drug more quickly than adults.

Please seek the advice of a medical professional before making health care decisions.

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Michelle Llamas, Senior Content Writer
Written By Michelle Llamas Senior Writer

Michelle Llamas has been writing articles and producing podcasts about drugs, medical devices and the FDA for seven years. She specializes in fluoroquinolone antibiotics and products that affect women’s health such as Essure birth control, transvaginal mesh and talcum powder. Michelle collaborates with experts, including board-certified doctors, patients and advocates, to provide trusted health information to the public. Some of her qualifications include:

  • American Medical Writers Association (AMWA) Engage Committee and Membership Committee member
  • Centers for Disease Control and Prevention (CDC) Health Literacy certificates
  • Original works published or cited in The Lancet, British Journal of Clinical Pharmacology and the Journal for Palliative Medicine
Edited By

11 Cited Research Articles

  1. Bollet, A.J., Black, R. & Bunim, J.J. (1955, June 11). Major Undesirable Side-Effects Resulting From Prednisolone And Prednisone. Retrieved from https://jamanetwork.com/journals/jama/article-abstract/300959
  2. Colorado State University. (2019). Glucocorticoids. Retrieved from http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/adrenal/gluco.html
  3. National Health Service. (n.d.). Steroid Tablets. Retrieved from https://www.nhs.uk/conditions/steroid-tablets/
  4. Pickup, M.E. (2012, December 15). Clinical Pharmacokinetics of Prednisone and Prednisolone. Retrieved from https://link.springer.com/article/10.2165/00003088-197904020-00004
  5. Puckett, Y., Gabbar, A. & Bokhari, A.A. (n.d.). Prednisone. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK534809/
  6. Ramsahai, J.M. & Wark, P.A.B. (2018, July 17). Appropriate use of oral corticosteroids for severe asthma. Retrieved from https://www.mja.com.au/journal/2018/209/2/appropriate-use-oral-corticosteroids-severe-asthma
  7. ScienceDirect. (n.d.). Elimination Half-Life. Retrieved from https://www.sciencedirect.com/topics/immunology-and-microbiology/elimination-half-life
  8. ScienceDirect. (n.d.). Prednisone. Retrieved from https://www.sciencedirect.com/topics/immunology-and-microbiology/prednisone
  9. U.S. National Library of Medicine. (2019, December 17). LABEL: PREDNISONE tablet. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=10fe5a3b-84dc-4600-87c2-b80c97ce18cf&audience=consumer
  10. U.S. National Library of Medicine. (2020, January 7). LABEL: RAYOS- prednisone tablet, delayed release. Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=281ab967-7565-4bef-9c0c-a646589c671e&audience=consumer#section-7
  11. U.S. National Library of Medicine. (n.d.). Prednisone. Retrieved from https://medlineplus.gov/druginfo/meds/a601102.html
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