Some shipments of L-citrulline, an amino acid supplement used to treat genetic disorders in children, can cause serious harm and in some cases could lead to death.
|Medical experts assign L-citrulline supplements for:|
|Certain genetic disorders||Erectile dysfunction|
|High blood pressure||Cardiovascular disease|
|Sickle cell anemia||Lysinuric protein intolerance|
Possible Side Effects and InteractionsBecause citrulline is created by the body, L-citrulline supplements are generally believed to be safe. Side effects are rare with the use of either pharmaceutical-grade or over-the-counter supplements. However, doctors advise women who are pregnant or nursing to avoid taking them. Scientific evidence about the supplements’ safety for women in these conditions is lacking. L-citrulline may interact with some prescription drugs, including certain medications used to treat hypertension, cardiovascular disease and erectile dysfunction. Individuals who take medications regularly, either prescription or over-the-counter, should consult a health care professional before taking L-citrulline.
Bad Lots Spur RecallIn February 2014, some pharmaceutical-grade L-citrulline supplements were recalled. Medisca Inc., a Plattsburg, N.Y.- based compounding firm, issued a voluntary recall of eight defective lots of its L-citrulline products, which are distributed to hospitals and pharmacies nationwide. According to a safety alert released by the FDA, these bad lots were found to contain no L-citrulline at all. Instead, FDA lab testing found that they contained N-acetyl-leucine, a drug used in the treatment of vertigo. Adverse reactions, some of them serious, have been reported in a number of children treated with these mislabeled supplements. The FDA advises health care professionals, caregivers and patients that Medisca L-citrulline products with the following lot numbers should not be used: