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Zostavax

Zostavax is a shingles vaccine made by Merck. From 2006 to 2017, it was the only shingles vaccine available in the U.S. The Centers for Disease Control and Prevention says Zostavax is 51 percent effective at preventing shingles. But the vaccine may cause serious side effects. Some people filed lawsuits against Merck after they say Zostavax injured them.

Zostavax vaccine
Zostavax Facts
  1. Use Protection against shingles (herpes zoster)
  2. Side Effects Shingles, chickenpox, autoimmune disorders, congestive heart failure, death, hearing loss, spinal cord inflammation, acute retinal necrosis and post-herpetic neuralgia
  3. Manufacturer Merck
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Zostavax (zoster live vaccine) is a vaccine for a painful rash called shingles. The same virus that causes chickenpox also causes shingles. The disease often occurs in people older than 60 years of age.

The U.S. Food and Drug Administration gave Merck approval to sell the vaccine in 2006. It was the only shingles vaccine in the U.S. until 2017.

Did You Know?
About 1 in 3 people in the U.S. will get shingles.
Source: Centers for Disease Control and Prevention, Shingles Overview

The vaccine reduces the risk of shingles by 51 percent, according to the Centers for Disease Control and Prevention.

Zostavax may also lead to rare but serious side effects. These include shingles, eye damage, nerve pain and death.

Some people who claim the vaccine injured them filed lawsuits against Merck.

How Does Zostavax Work?

Zostavax is a live attenuated vaccine. This means it contains a weak, living form of the varicella-zoster virus. This virus causes chickenpox and shingles.

The body produces antibodies to fight the weak virus strain. This strengthens the body’s immune system to fight shingles.

Zostavax Side Effects

As of March 2018, the FDA had received 102,962 reports of Zostavax side effects. These include 80 deaths, according to the Vaccine Adverse Event Reporting System (VAERS).

Redness, pain, injection site bruising and headache are the most common side effects.

Common Zostavax Side Effects
  • Chickenpox
  • Fever
  • Headache
  • Joint pain
  • Muscle pain
  • Nausea
  • Rash at injection site
  • Shingles
  • Swollen glands near injection site

Serious Side Effects

Some people reported rare, serious Zostavax side effects. Two of these are nerve and eye damage.

Post-herpetic neuralgia (PHN) is nerve pain or damage caused by the shingles virus. Lawsuits reported some people suffered PHN after receiving Zostavax.

Acute retinal necrosis (ARN) is a severe viral infection of the eye. It can lead to blindness. Some studies found people who received Zostavax developed ARN.

Serious Zostavax Side Effects
  • Acute retinal necrosis (severe eye infection)
  • Allergic reactions
  • Autoimmune disorders
  • Congestive heart failure
  • Death
  • Hearing loss
  • Post-herpetic neuralgia (nerve pain or damage)
  • Spinal cord inflammation

How Long After Taking Zostavax Do Side Effects Occur?

Side effects of Zostavax may happen in minutes or take months to surface. Many side effects last only a few days.

Fact
About 1 in 70 people reported headaches after Zostavax vaccination.
Source: The Centers for Disease Control and Prevention

Allergic reactions or arm pain may occur within minutes or hours of vaccination. Serious side effects may take longer to develop.

A woman in a 2011 study suffered vision loss after six days. A man developed a rash and fever within a few days of receiving Zostavax. He lost his vision two months later.

How Zostavax Is Given

Health care providers administer Zostavax in one shot. The shot contains one .65 mL dose. The vaccine goes into the skin of the upper arm.

Doctor giving patient vaccine insulin or vaccination
Health care professionals administer Zostavax via a shot into the skin of the upper arm

Who Should Not Get Zostavax?

Zostavax is not safe for everyone. Those who have allergies or medical problems should tell their doctor before getting the vaccine. Children and pregnant women should not receive Zostavax.

Adults Should Not Get Zostavax If They:
  • Are allergic to its ingredients
  • Have a weakened immune system
  • Take medicine that might weaken the immune system
  • Are pregnant or might become pregnant
  • Are allergic to neomycin or gelatin

How Do I Pay for Zostavax?

Most private health insurance plans cover the shingles vaccine for little to no cost. Medicare Part D and Tricare also cover the shingles vaccine.

Some drug companies may provide vaccines to people who cannot afford them.

Zostavax is a part of the Merk Vaccine Patient Assistance Program. People who do not have health insurance and who meet household income criteria may qualify.

Ingredients in Zostavax

Zostavax includes ingredients intended to preserve the vaccine and keep it safe. But some of these ingredients may cause allergic reactions in people.

Ingredients in the 2016 Zostavax label include:
  • Sucrose
  • Hydrolyzed porcine gelatin
  • Sodium chloride
  • Monosodium L-glutamate
  • Sodium phosphate dibasic
  • Potassium phosphate monobasic
  • Potassium chloride
  • Components of MRC-5 cells (DNA, protein)
  • Neomycin
  • Bovine calf serum
  • Urea (refrigerator stable only)

Zostavax vs Shingrix

A newer shingles vaccine called Shingrix came out in 2017. The CDC recommends Shingrix over Zostavax. The following table shows how Zostavax compares to Shingrix.

Zostavax Compared with Shingrix
Category Zostavax Shingrix
Manufacturer Merck GlaxoSmithKline
FDA Approval Date 2006 2017
Average Cost $200 per shot $280 per shot
Dose 1 shot 2 shots over two to six months
Effectiveness 51% in adults 60 to 69, significant decrease in adults 70 and over 97% in adults 50 to 69 years, 91% in people 70 and over
Adjuvant (ingredient that improves effectiveness) No Yes
Safe for People with Weak Immune System No Yes
Vaccine Type Made with weakened live virus Made with non-live virus DNA
Storage Refrigerated No refrigeration required
Recommended Starting Age 60 50

Zostavax Lawsuits

Some people claim they suffered serious side effects from Zostavax. They filed Zostavax lawsuits against Merck.

Lawsuits say the live virus in Zostavax may lead to developing shingles. They also blame the vaccine for other injuries ranging from vision loss to death.

One man sued after he said lost his ability to walk after receiving Zostavax. Another woman said Zostavax injured her right eye.

Drugwatch’s legal partners are currently accepting cases.

Please seek the advice of a medical professional before making health care decisions.

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7 Cited Research Articles

  1. CDC. (2018, March 14). The Vaccine Adverse Event Reporting System (VAERS). Retrieved from https://wonder.cdc.gov/vaers.html
  2. Charkoudian, L.D. et al. (2011 November). Acute retinal necrosis after herpes zoster vaccination. Retrieved from https://jamanetwork.com/journals/jamaophthalmology/fullarticle/1106674/
  3. FDA. (2017). Patient Information about Zostavax (pronounced “ZOS tah vax”) Generic name: Zoster Vaccine Live. Retrieved from https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM176340.pdf
  4. ProCon.org. (n.d.). Vaccine ingredients and manufacturer information. Retrieved from https://vaccines.procon.org/view.resource.php?resourceID=005206#zoster
  5. U.S. National Library of Medicine. (2018). ZOSTAVAX- zoster vaccine live injection, powder, lyophilized, for suspension STERILE DILUENT- sterile water injection. Retrieved https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=30a0464e-e012-4c16-bc05-88f07e412203&audience=consumer
  6. CDC. (2018, February 23). Shingles Surveillance. Retrieved from https://www.cdc.gov/shingles/surveillance.html
  7. FDA. (2018). Highlights of Prescribing Information. Retrieved from https://www.fda.gov/downloads/BiologicsBloodVaccines/Vaccines/ApprovedProducts/UCM132831.pdf
View All Sources
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