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Multiple medical studies link the Type 2 diabetes medication Actos to the onset of bladder cancer. That life-threatening side effect, as well as heart failure, led thousands of people to seek compensation for damages caused by the drug. Drug maker Takeda Pharmaceuticals in April 2015 settled about 9,000 Actos-related lawsuits for $2.37 billion.
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Each year in the United States, about 70,000 people are diagnosed with bladder cancer. If caught before it spreads, the cancer can usually be treated. However, it has a high recurrence rate. Takeda does not acknowledge any links between Actos and bladder cancer.Learn More
The FDA considers the risk of congestive heart failure from Actos to be significant enough to require a black-box warning on the drug's label. Avandia, another drug in the same class, is also known to cause severe heart problems.Learn More
Takeda and Eli Lilly launched Actos, a thiazolidinedione (TZD). Pre-approval studies showed tumors in rats given the drug. Its label said the relationship between the tumors in rats and possible tumors in humans is "unclear."
Actos is found to increase the risk of congestive heart failure.
Two clinical studies that were a part of Takeda's PROactive study revealed a higher percentage of bladder cancer in people taking Actos as opposed to another drug.
The FDA upgrades Actos label to its most extreme black-box warning to highlight risk of heart failure.
A study finds that Actos doubles the risk of fractures in post-menopausal women.
A study finds Actos more than doubles the risk of an eye disorder (macular edema) that can cause reduced vision and blindness.
FDA begins reviewing data from 10 year Actos study.
French study finds increased bladder cancer risk in patients taking Actos. The drug is pulled off market in France, and Germany recommended not starting Actos in new patients.
FDA releases safety announcement warning that using Actos for over a year "may be associated with a 40% increased risk of bladder cancer." First Actos bladder cancer suits are filed.
Federal lawsuits are combined into multidistrict litigation (MDL) in Louisiana. The number is expected to reach 10,000.
Former employee Dr. Helen Ge sues Takeda, accusing the company of hiding Actos side effects information from the FDA.
Judge’s order allows patients to join the MDL by filing their lawsuit directly with the Louisiana court. Dr. Helen Ge’s whistle-blower lawsuit is dismissed.
Jury awards $9 billion to Terrence Allen. The award is cut to $37 million in October. First test trial in federal MDL.
Takeda settles about 9,000 claims filed about Actos for at least $2.37 billion, one of the largest Big Pharma settlements in U.S. history. As part of the agreement, the drug maker does not admit any wrongdoing.
Louisiana resident Darin Andrews filed a lawsuit against Takeda in 2012 after being diagnosed with bladder cancer several months after he started taking Actos. His lawsuit states the drug was "inadequately tested, dangerous to human health and lacked proper warnings."
Edwene Person's husband, James, was diagnosed with and died from bladder cancer after taking Actos. Her lawsuit states that James' injuries were a result of the defendants' "wrongful conduct, acts, omissions, [and] fraudulent misrepresentations."
With mounting evidence that the type 2 diabetes drug Actos has a direct link to bladder cancer, heart failure and bone fractures, and with growing suspicion that the drugmaker hid those problems, injured patients nationwide are turning to qualified attorneys for help in navigating the legal system.
People seek legal assistance because they need money to cover substantial damages that can result from Actos use. If you have suffered complications from Actos, the physical, emotional and financial costs will likely be high. You may be eligible for financial compensation for substantial losses and expenses related to your injuries. But first, you have to prove that the companies behind Actos are liable for your injuries.
It helps to have someone who is familiar with the pharmaceutical industry on your side. Actos attorneys are experienced in investigating dangerous drug claims and understand how prescription drugs are marketed. They know what’s needed to prove liability in drug cases.
Before contacting a lawyer, you should fully understand your legal rights and options. We can help you understand how to move forward and what the legal process will be like.