Effexor
Venlafaxine hydrochloride
Effexor, Effexor-XR
Effexor is used in the treatment of a number of mental illnesses, including major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder. The medication is an antidepressant included in a group of drugs known as selective serotonin and norepinephrine reuptake inhibitors which correct imbalances in the brain to treat mental illnesses.
Effexor is used in the treatment of depression, generalized anxiety disorder, social anxiety disorder, and panic disorder.
Depression is a chronic illness that involves both the mind and the body and requires long-term treatment. Symptoms include:
- Lack of interest in normal daily activities
- Feeling sad, hopeless or worthless
- Crying for no reason
- Sleeping problems
- Difficulty focusing, concentrating or making decisions
- Weight gain or loss
- Irritability or being easily annoyed
- Restlessness
- Feeling tired or weak
- Loss of interest in sex
- Thoughts of suicide or suicidal behavior
- Unexplained physical problems
Generalized anxiety disorder is a feeling of ongoing anxiety that interferes with daily life. Symptoms include:
- Constant worry or obsession with small or large issues
- Feeling restless or on edge
- Tiredness
- Difficulty concentrating
- Irritability
- Muscle tension or aches
- Trembling, twitching or being easily startled
- Difficulty sleeping
- Sweating
- Nausea or diarrhea
- Shortness of breath
- Rapid heartbeat
Social anxiety disorder occurs when everyday interactions cause extreme anxiety, worrying and fear. The condition may disrupt daily routines, work, school or other activities. Symptoms include:
- Intense fear of people you do not know
- Fear of being judged
- Worrying about embarrassing or humiliating yourself
- Fear that others will notice your anxiety
- Avoiding situations where you might embarrass yourself or be noticed
- Blushing
- Sweating
- Trembling or shaking
- Nausea, upset stomach or diarrhea
- Difficulty talking or shaky voice
- Muscle tension
- Confusion
- Palpitations
- Cold, clammy hands
- Difficulty making eye contact
Panic disorder involves sudden attacks of intense fear that develop for no apparent reason. Those who are treated for severe anxiety attacks typically have panic attacks relatively frequently. Symptoms include:
- Rapid heart rate or chest pain
- Hyperventilation
- Shortness of breath
- Sweating, chills or hot flashes
- Trembling
- Nausea
- Abdominal cramping
- Headache
- Dizziness
- Faintness
- Tightness in your throat or difficulty swallowing
- A sense of impending death
Effexor works by affecting neurotransmitter activity in the central nervous system. It inhibits seratonin and norepinephrine reuptake and inhibitors of dopamine reuptake. It is hypothesized that Effexor is associated with anticholinergic (blocking part of the central nervous system), sedative and cardiovascular effects that are the results of other psychotropic drugs. Effexor works to balance substances within the brain to elevate the mood of patients taking the drug.
The following medications are not recommended to be used in combination with Effexor. Your doctor may decide to prescribe alternate medications:
- Furazolidone
- Iproniazid
- Isocarboxazid
- Linezolid
- Metoclopramide
- Moclobemide
- Nialamide
- Pargyline
- Phenelzine
- Procarbazine
- Selegiline
- Toloxatone
- Tranylcypromine
- Trifluoperazine
Speak with your doctor about additional medications that may negatively interact with Effexor.
Typical Dosage Recommendations
Effexor is available as a tablet, while Effexor XR is an extended release capsule. The dose of Effexor is different for different patients. If your dose is different, do not change it unless instructed by your doctor.
Depression: The initial extended release tablet dose for adults is 75 mg per day, divided into two doses taken morning and evening. Your dose may be adjusted as needed. The dose should not exceed 225 mg per day.
The initial tablet dose is 75 mg per day, divided into doses to be taken two to three times per day. The dosage usually does not exceed 375 mg per day.
Anxiety: The initial extended release capsule dose for adults is 75 mg per day taken as a morning dose and evening dose for 7 days. The dosage may be adjusted as needed and will not exceed 225 mg per day.
Panic Disorders: The initial extended release capsule dose for adults is 37.5 mg per day, taken as one dose in the morning or evening for 7 days. The dosage may be adjusted and will not exceed 225 mg per day.
Missing a Dose
If you miss a dose of Effexor, take it as soon as possible. If it is time for your next dose, skip the missed dose and resume your dosing schedule. Do not double dose. If you are taking Effexor XR, do not take more than one dose per day.
Overdosing
Most patients with documented cases of Effexor overdose reported no symptoms, but there are 14 known cases in which all recovered with the proper intervention. Most cases of overdose have occurred in combination with other drugs and/or alcohol. Symptoms of overdose can include:
- Ventricular tachycardia
- Hypotension
- Bradycardia
- Vertigo
- Liver necrosis
- Rhabdomyolysis
- Serotonin syndrome
- Possibly death
Seek immediate medical attention following an overdose of Effexor.
Effexor: December 28, 1993
Effexor XR: October 20, 1997
Effexor contains a Black Box warning related to an increase in suicidal thoughts and behavior when used in children, teenagers, and young adults with depression. Patients who initiate treatment on antidepressants should be carefully monitored for worsening depression, suicidal tendencies or unusual changes in behavior.
- http://www.mayoclinic.com/health/drug-information/DR601617/DSECTION=proper-use
- http://www.mayoclinic.com/health/depression/DS00175
- http://www.mayoclinic.com/health/generalized-anxiety-disorder/DS00502
- http://www.mayoclinic.com/health/social-anxiety-disorder/DS00595
- http://www.mayoclinic.com/health/panic-attacks/DS00338
- http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.DrugDetails
- http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=10194
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