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Study: PPI Acid Reflux Drugs Overused in People with GI Bleeds

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More than half of patients with gastrointestinal (GI) bleeding receive acid reflux drugs called proton pump inhibitors (PPIs) even when guidelines discourage their use, according to a study.

University of Chicago researchers found as many as 65 percent of patients admitted to hospitals with upper GI bleeding receive IV infusions of PPIs such as Nexium (esomerazole) or Prilosec (omeprazole) even when their use is discouraged.

The inappropriate use of PPI drips increases the cost and decreases patient comfort and mobility, the study found. Researchers presented their findings at the 2016 Digestive Disease Week. They also created a system to warn about improper use of therapy.

“Our primary aim was really to promote the appropriate use of PPI drips in upper GI bleedings, since we saw such high numbers of inappropriate use,” Dr. Emmanuel Coronel, lead study author and gastroenterology fellow at the University of Chicago Medicine, told Gastroenterology & Endoscopy News.

Some patients with a low-risk ulcer or another type of lesion causing upper GI bleeding should receive an oral PPI drug or an intermittent dose instead of a continuous IV, researchers said. After following researchers’ guidelines, the inappropriate use of PPI drips dropped. Annual savings were estimated at $93,000.

PPI drugs are some of the most commonly used medications in the U.S. About 20 million Americans take these acid-reducing drugs and spend $14 billion on them each year.

Some experts feel they are overused, and new studies show long-term use of PPIs can lead to a number of side effects. In fact, a San Francisco Department of Public Health study estimated 60 to 70 percent of people who take PPIs would benefit more from lifestyle changes and antacids.

In 2010, the U.S. Food and Drug Administration warned that these drugs can lead to increased risk of bone fracture and infections. Some studies even link the medications to an increased risk of heart attack.

PPIs Linked to Kidney Damage

In addition to the warnings released by the FDA, studies also link PPIs to an increased risk of kidney damage. In fact, a study published in 2015 in the Pharmaceutical Journal revealed, “All PPIs are associated with acute interstitial nephritis.”

Data from studies continues to show a link between PPIs and kidney disease and damage.

For example, a study published in a 2016 JAMA journal showed PPI users had a 15.9 percent risk of developing kidney disease over 10 years. People with kidney disease were also twice as likely to have used a PPI in the past, according to a study published by BMC Nephrology in 2013.

PPI Side Effects Lead to Lawsuits

The link between kidney injuries and PPIs led to a number of patients filing lawsuits against the drug’s makers.

In June 2016, Terry Buzbee filed suit against AstraZeneca and Takeda Pharmaceuticals after he said Nexium and Prevacid caused his acute kidney injury. According to Buzbee’s complaint, “defendants concealed knowledge of Nexium and Prevacid’s defects, from Plaintiff, the FDA the public in general and/or the medical community specifically.”

Buzbee used Nexium and Prevacid for about 10 years and suffered acute kidney injury that required hospitalization and caused permanent injury, the court documents said.

Last modified: February 21, 2017


Michelle Y. Llamas is a senior content writer. She is also the host of Drugwatch Podcast where she interviews medical experts as well as patients affected by drugs and medical devices. She has written medical and legal content for several years — including an article in The Journal of Palliative Medicine and an academic book review for Nova Science Publishers. With Drugwatch, she has developed relationships with legal and medical professionals as well as with several patients and support groups. Prior to writing for Drugwatch, she spent several years as a legal assistant for a personal injury law firm in Orlando. She obtained her English – Technical Communication degree from the University of Central Florida. She is a committee member with the American Medical Writers Association.

Hide Sources

  1. Gastroenterology & Endoscopy News. (2016, August 15). Study Promotes Appropriate Use of PPI Drips for GI Bleeding. Retrieved from
  2. Buzbee v. AstraZeneca et al. (2016, June 13). Complaint and Demand for Jury Trial. Case 1:16-cv-02934-ARR-CLP
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