GlaxoSmithKline is a Big Pharma corporation. It sits at No. 194 on Forbes’ list of the 2,000 largest companies in the world.

The British pharmaceutical company is well-known for its respiratory products like Advair and Ventolin.

But GSK has faced allegations of unethical and unsafe business practices. Some of its former employees were criminally prosecuted on two different continents.

Some of GSK’s popular pharmaceuticals have harmed patients. Injuries led to product liability lawsuits.

GlaxoSmithKline is a global health care company with headquarters in Brentford, London.

Emma Walmsley is GSK’s CEO. She is the first woman to be chief executive of a major pharmaceutical corporation.

Total revenues for GSK reached $30.2 billion pounds in 2017. This equates to $40.4 billion in U.S. currency.

GSK employs nearly 100,000 people in over 150 countries. Its U.S. headquarters are in Philadelphia. GSK has a separate research facility in North Carolina.

GlaxoSmithKline started in 1715 as Plough Court pharmacy, a small apothecary shop in London. GSK evolved through a series of mergers over two centuries.

GSK focuses on vaccines, pharmaceutical drugs and consumer health care products. It sold 798 million doses of vaccines in 2017.

GSK is the maker of the industry’s broadest range of inhaled respiratory products. These include Advair, Ventolin and Breo Ellipta. The products are the company’s biggest moneymaker.

The company has also partnered with Pfizer and Shionogi to form a global HIV business, ViiV Healthcare. The business accounts for more than 20 percent of GlaxoSmithKline’s pharmaceutical sales.

GlaxoSmithKline has faced a number of product liability lawsuits. Patients filing lawsuits accuse the company of manufacturing dangerous or defective products.

Suicidal thoughts and birth defects

Strokes, heart attacks and heart failure

Birth defects

GSK faced 445 Zofran lawsuits in May 2018.

In 2012, GlaxoSmithKline pleaded guilty to federal criminal offenses. The company’s crimes included misbranding of its antidepressants Paxil and Wellbutrin. GSK also failed to report safety data to the FDA about its diabetes drug Avandia.

GSK admitted to illegally promoting Paxil for treatment of depression in children.

The company reached a civil settlement with the U.S. federal government in which it agreed to pay a fine of $3 billion.

The plea represented the largest health care fraud settlement in U.S. history. It resolved allegations of pricing fraud.

GSK reached a related civil settlement with the U.S. Justice Department. It resolved allegations of improper marketing of Advair and Zofran.

GlaxoSmithKline recalled some of it products for defects, possible tampering and reduced effectiveness. Products affected include consumer weight loss products, vaccines and albuterol inhalers.

A Chinese court ordered GlaxoSmithKline to pay $492 million in 2014. The fine resolved charges of bribing doctors in China to use GSK products. It was the biggest penalty ever imposed by a Chinese court.

The court sentenced Briton Mark Reilly to four years in prison. He was the company’s British executive for China. Four other Chinese employees received the same punishment.

But the employees may never serve prison time. The court postponed the sentences. Reilly was deported.

In February 2018, GSK was still answering to fraud investigators in its home country.